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FUTURE ONCOLOGY
Volume 3 # 2/3 June/July 1997
State-of the-Art in the Management of Cancer

OVARIAN CANCER-PART IV

Novel Therapeutic Approaches in Development

Analogs, Derivatives and Formulations of Agents Approved for the Treatment of Ovarian Cancer

Anthracyclines

  • Anthra Pharmaceuticals

Platinum Analogs

  • Oxaliplatin

Taxanes

  • Paclitaxel
  • Docetaxel

Topoisomerase I Inhibitors

  • GW211

Gemcitabine

Drug Resistance

Methionine

  • AntiCancer

Molecular Markers

Resistance to Platinum-based/Alkylating Agents

  • Intracellular glutathione
  • Metallothioneins

Resistance to Taxanes

  • SDZ PSC 833

Chemoprotection

  • Genetix Pharmaceuticals
  • Ingenex

Immunotherapy/vaccines

  • AltaRex
  • Avax Technologies
  • Biomira
  • Corixa
  • Trilex Pharmaceuticals
  • Other

Small Molecule Drugs

  • CDR Therapeutics
  • Sugen

Radioisotopes/Radioimmunoconjugates

  • Immunomedics
  • NeoRx
  • University of Alabama
  • University of Chicago

Photodynamic Therapy

Inhibition of Metastasis

  • Anika Therapeutics

Molecular Approaches to Management of Ovarian Cancer

BRCA 1/BRCA2

p53

ras

  • Cortecs International

Her-2/neu (erbB-2)

  • Anti-erbB-2 sFv (Ad21)

EGFr

Mechanisms in Malignancy

The Cell Cycle

Cell Cycle Control

Growth Signals

Cyclins and Cyclin-dependent Kinases

  • Targets of cyclins and cdks

Mechanism of Action of the Retinoblastoma (Rb) Tumor Suppressor

  • E2F regulation by cell cycle-dependent changes in subcellular localization
  • Molecular mechanisms of E2F transcriptional regulation.

Cell Cycle Dysregulation and Cancer

Cellular Response to Oncogenic Mutation

  • p53
  • The role of p57 (KIP2)
  • Apoptosis

Viral Oncogenes

Diagnostic/Prognostic Applications of Cell Cycle

  • Cascade Oncogenics

Cell Cycle Modulation as an Anti-cancer Strategy

Direct Inhibitors of Cyclin:cdk

  • Flavoperidol
  • Olomoucine and roscovitine

Inhibitors of Activation or Activators of Inhibition of Cdk

Activators of Cyclin:cdk Proteolysis

Transcriptional Factors

Chemoprotection

Chemosensitization

  • UCN-01

Drug Development and Research Projects

Small Molecule Drugs

  • Mitotix
  • Onyx
  • ProScript

Peptide Mimetics

  • Cyclacel

Oligonucleotide-based Drugs

  • Gilead Sciences

Meeting Coverage

Demystifying the Role of Cytokines in Tumor Immunobiology: Status and Future Utility

Report from the 88th Annual Meeting

of the American Association for Cancer Research

April 12-16, 1997 San Diego, CA

 

Mechanisms of Gene Regulation by Tumor Necrosis Factor (TNF)

Flt 3 ligand (Flt-3L)

IL-6 Receptor Super-antagonists (SANTs): New Tools for Multiple Myeloma

Cytokines that Prevent or Promote Tumor Cell Death

  • EBV-associated Lymphoma
  • EBV-associated AIDS Primary CNS Lymphomas (AIDS-PCNSL)
  • Natural Killer (NK) Cell Leukemias

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