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FUTURE ONCOLOGY
Volume 4 #3/4 July/August 1998
State-of-the-Art in the Management of Cancer and Meeting Coverage

Prostate Cancer-PART IV
NOVEL TREATMENT APPROACHES IN DEVELOPMENT

Mechanisms in Prostate Cancer

  • Androgen and its Receptor
  • Apoptosis
  • FGN-1

Growth Factors

  • The fibroblast growth factor (FGF) family
  • Insulin-like growth factors-1 and II
  • Vascular endothelial growth factor (VEGF)
  • Epidermal growth factor (EGF) family

Metastasis, Angiogenesis and Cell Adhesion

  • Thalidomide
  • SU5416
  • Neovastat
  • AG3340
  • Interferon b
  • ABT-627

Antigen Expression

Other Molecular Markers

  • Reprogen

Hormone Therapies

  • Abarelix
  • 17-Azolyl Steroids
  • Cetrorelix
  • Gonadimmune
  • MZ471
  • PC-SPES
  • Vapreotide
  • YM116

Combination Therapies

  • LH-RH Agonists and Antiandrogens
  • Combination Therapies of Approved Chemotherapeutics
  • Combination Therapies using Drug Resistance Modulators
  • Biricodar dicitrate

Novel Chemotherapeutics

  • Biochanin A
  • Diphenylureas
  • Flavoperidol
  • JM-216
  • Liarozole
  • Molecular Motor Proteins
  • Perillyl Alcohol
  • Phenylbutyrate
  • Roquinimex
  • Suramin
  • Tributyrin
  • Vitamin D Analogs

Immunotherapy/Vaccines

Cancer Cells as Antigen Presenting Cells

Anti-PSA Strategies

  • Immunization with microbial vectors expressing PSA
  • Prostvac
  • BCG-based immunotherapeutic vaccines that express PSA
  • ProstaRex
  • OncoVax-Pr

Transfection of Cytokine Genes into Tumors

  • Cell Genesys

Autologous Dendritic Cells Incorporating Tumor-specific Antigens

  • Dendreon
  • Northwest Biotherapeutics

Vaccines Based on Other Prostate Cancer Associated Antigens

  • Globo H
  • MUC1 and MUC2

Gene Therapy

  • Suicide Gene Therapy using Adenovirus Vectors
  • Adeno-associated Viral (AAV) Vectors
  • Avigen

Prostate-Attenuated Replication Competent Adenovirus (ARCA)

  • Calydon
  • University of Michigan
  • University of Tennessee

Monoclonal Antibodies

PSMA MAb Immunoconjugates

  • BZL Biologics

Antibody-Directed Cytotoxicity

  • Medarex

Antisense Strategies

  • Genta
  • Isis Pharmaceuticals

Photodynamic Therapy

  • Miravant

Other Treatment Strategies

  • Cytotoxic Analogs of Somatostatin Containing Doxorubicin or its Derivative, 2-Pyrrolinodoxorubicin
  • Membrane Interactive Molecules (MIMs)
  • Demeter BioTechnologies
  • Macrophage Activating Factor

Prevention Strategies

  • Aromatase Inhibitors
  • Antioxidants

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