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FUTURE ONCOLOGY
Volume 5 #10/11 July 30, 2000
State-of-the-Art in the Management of Cancer

LUNG CANCER-PART VI

Novel Agents/Formulations in development

Novel Chemotherapeutics

Spindle Poisons

Anhydrovinblastine

BMS-184476

Maytansinoid immunoconjugates

PG-TXL

Taxoprexin

T67

 

Topoisomerase I Inhibitors

Exatecan mesylate

TAS-103

XR5000

 

Antifolates

Alimta

S-1

 

Nucleosides

Decitabine

FMdC

 

Platinum-based Agents

Nedaplatin

            Oxaliplatin

Satraplatin

 

Other Agents

Bendamustin

CHS 828

            CI-994

            Irofulven

Temozolomide

            Tirapazamine

 

Novel Formulations And Drug Delivery Approaches

Lipid Formulations

Onco TCS

Liposome-encapsulated paclitaxel (LEP)

 

Aerosol Delivery

Aerosol doxorubicin

Aerosol retinoids

Aerosolized GM-CSF

            Inhaled RFS 2000

 

Angiogenesis Inhibitors

Matrix Metalloproteinase Inhibitors (MMPI)

BMS-275291

Marimastat

Neovastat

Prinomastat

 

Angiostatin and Endostatin

Squalamine

VEGF Antagonists

            Angiozyme

rhuMAb-VEGF

            Semoxind

 

Other Agents

BN-50730

 

Regulation

Cell Cycle Regulation

Flavopiridol

UCN-01

 

Approaches Targeting the Epidermal Growth Factor Receptor (EGFr)

ABX-EGF

Trastuzumab

ZD 1839

 

Farnesyl Tranferase Inhibitors (FTI)

R115777

SCH 66336

 

Approaches Targeting p53

rAd/p53

RPR/INGN 201

ONYX-015

 

Agents Targeting Other Markers

G3139

ISIS 3521

 

Immunotherapy/Vaccines

Cytokine-producing Tumor Vaccines

SRL172

Vaccines Against CEA-expressing Tumors

Anti-CEA antibodies

Recombinant viruses expressing CEA protein or peptides

Dendritic cells expressing CEA

 

Vaccines Against Ganglioside-expressing Tumors

Fucosyl-GM1-keyhole limpet hemocyanin (KLH) conjugate vaccine

Mitumomab (BEC2)

 

Vaccines Against MUC-1-expressing Tumors

BLP-25

 

Vaccines Against Tumors Expressing HER2

HER2 Peptide Vaccine

 

Radiation Therapy

Radioimmunoconjugates

Pantacea

 

Radiosensitizers

KIN-806

Motexafin gadolinium

            RSR-13

 

Proton Beam Therapy

 

Chemoprevention

Vitamins

Celecoxib

Exisulind

Retinoids

Thymalfasin


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