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FUTURE ONCOLOGY
Volume 6 #10/11 February 15, 2002


Anticancer Drugs and Markets

UPDATE ON SPINDLE POISONS - PART I
TAXANES, GENERIC PACLITAXEL, AND NOVEL FORMULATIONS AND ANALOGS

Current Markets for Commercially Available Taxanes

Mechanism of Action of Taxanes and Spindle Poisons

  • Mechanism of Action of Taxanes
  • Drug Resistance
    • Cyclosporin A (CsA) and its analogs/derivatives
    • GF120918
    • ONT-093
    • R101933
    • tRA96023
    • VX-710
    • XR9576
  • Chemosensitization
    • AVI-4557
  • Toxicity
    • BNP7787
    • Prosaptide
Approved and/or Commercially Available Taxanes
  • Paclitaxel
    • Taxol
    • Paxene
  • Docetaxel
    • Taxotere>
Taxane Sources, Production Processes, and Generic Paclitaxel
  • Abbott Laboratories
  • Aphios
  • Biolyse Pharma
  • Dabur India
  • eXegenics
  • Faulding
  • Indena
  • Ivax
  • Mylan Pharmaceuticals
  • NaPro BioTherapeutics
  • Natural Pharmaceuticals
  • Phytogen Life Sciences
  • Phyton
  • Samyan Genex
  • Xechem International
Novel Formulations
  • ABI-007
  • CT-2103 (PG-TXL)
  • Fibrinogen-Coated Emulsion Formulation of Docetaxel
  • Genetaxyl
  • Liposome-encapsulated paclitaxel (LEP)
  • OncoGel
  • Paclimer Microspheres
  • PacoExtra
  • Paxoral
  • PEG-paclitaxel
  • S-8184
  • SP5.210C
  • Taxoprexin
  • Taxosomes/Dermos
Novel Taxanes and Analogs
  • BAY 59-8862 (IDN5109)
  • BMS-184476
  • BMS-188797
  • BMS-275183
  • DJ-927
  • RPR109881
  • RPR116258A
  • TL-139
  • Tumor-activated Prodrug (TAP)-Taxane Immunoconjugates
  • TXD258 (TAX 258)
Novel Spindle Poisons

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