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Future Oncology - Technology, Products, Markets, and Service Opportunities

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FUTURE ONCOLOGY - TECHNOLOGY, PRODUCTS, MARKETS, AND SERVICE OPPORTUNITIES IN THE CANCER FIELD

FUTURE ONCOLOGY
Volume 7 #8/9 November 15, 2003


STATE-OF-THE-ART IN THE MANAGEMENT OF CANCER

PANCREATIC CANCER PART I
EPIDEMIOLOGY, ETIOLOGY, MOLECULAR MARKERS, DIAGNOSIS, AND STAGING

TYPES OF PANCREATIC CANCER
  • Pancreatic Intraductal/Intraepithelial Neoplasia (PanIN)
  • Exocrine Pancreatic Cancer
    • Pancreatic ductal adenocarcinoma (PDAC)
    • Mucinous cystic neoplasms
    • Intraductal papillary mucinous tumors (IPMT)
  • Neuroendocrine Pancreatic Tumors

EPIDEMIOLOGY

ETIOLOGY OF PANCREATIC CANCER

  • Epigenetic Events
  • Hereditary Factors
  • Smoking
  • Other Risk Factors

MOLECULAR MARKERS

SCREENING

DIAGNOSIS, PROGNOSIS AND DISEASE MONITORING

  • Biopsy
  • In vitro Diagnostics
    • CA19-9
    • CA50
    • CA195
    • CA242
    • Carbonic anhydrase 3 (CAR-3)
    • PaCa-Ag1
    • Molecular Beacons
  • In vivo Diagnostics
    • Endoscopic retrograde cholangiopancreatography (ERCP)
    • Endoscopic ultrasound (EUS)
    • Computed tomography (CT)
    • Ultrasound imaging
    • Magnetic resonance (MR)
    • Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET)
    • OctreoScan

STAGING OF PANCREATIC CANCER

  • Incidence by Stage
  • 5-year Survival by Stage

LIST OF EXHIBITS

Exhibit 1 - Worldwide Incidence of Pancreatic Cancer in 2002

Exhibit 2 - Worldwide Mortality from Pancreatic Cancer in 2002

Exhibit 3 - Incidence of Pancreatic Cancer in the Developed World in 2002

Exhibit 4 - Mortality from Pancreatic Cancer in the Developed World in 2002

Exhibit 5 - Estimated Age-adjusted Incidence Rates (per 100,000) by Age and Race in the USA (1966-2000)

Exhibit 6 - Molecular Markers Associated with Pancreatic Cancer

Exhibit 7 - Staging of Pancreatic Cancer

Exhibit 8 - Estimated Incidence by Stage of Pancreatic Cancer in the USA in 2003 and 5-year Survival


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