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Future Oncology - Technology, Products, Markets, and Service Opportunities

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FUTURE ONCOLOGY - TECHNOLOGY, PRODUCTS, MARKETS, AND SERVICE OPPORTUNITIES IN THE CANCER FIELD

FUTURE ONCOLOGY
Volume 8 #5 June 2005


MEETING COVERAGE

TARGETING FOR CANCER IMAGING AND THERAPY
FROM THE "IMMUNE, VASCULAR AND GENE TARGETING FOR CANCER IMAGING AND THERAPY" MEETING ORGANIZED BY THE SIDNEY KIMMEL CANCER CENTER
IN SAN DIEGO, CA. FEBRUARY 28-MARCH 2, 2005

DELIVERY OF DRUGS TO TUMORS
  • Enhancing Dilivery of Drugs to Tumors
    • Stem cells
    • Multivalent monoclonal antibodies (MAb)
    • Polymerized vesicles (PV)
    • Pulsed high intensity focused ultrasound (HIFU)
    • TC1 MAb
    • Adoptive cell transfer (ACT)
  • Gene transfer
    • Lentiviral vectors

THERAPEUTIC APPROACHES IN DEVELOPMENT

  • Apoptosis Enhancing Approaches
    • Bcl-2
  • Oncogene Inactivation
    • PSF protein and mouse VL30 (mVL30) retrotransposon RNA complexes
    • Oligonucleotides against jun kinase (JNK)
    • MDX-010
  • Angiogenesis Inhibitors/Antimetastatic Agents
    • Avastin
    • SKI-606
  • Oncolytic Measles Virus

TECHNOLOGY ADVANCES

  • Proteomics
    • FLEXGene (Full Length EXpression-ready) repository
  • Target Identification in Prostate Cancer

DIAGNOSIS, PROGNOSIS AND DISEASE MONITORING

  • Molecular Portraits by Cancer Type
  • Serum-based Approaches
  • Tumor Hypoxia
  • Stem Cells
  • MALDI (Matrix Assisted Laser Desprption Ionization) Mass Spectrometry

MECHANISMS IN MALIGNANCY

THE c-Src SIGNAL TRANSDUCTION PATHWAY THE Src KINASE FAMILY (SKF) c-Src
  • Bone Metabolism
  • Regulation of Angiogenesis
  • Promotion of Metastasis

MALIGNANCIES ASSOCIATED WITH c-Src

  • Bone Cancer
  • Breast Cancer
  • Chronic Myelogenous Leukemia (CML)
  • Colorectal Cancer
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer

AGENTS IN DEVELOPMENT TARGETING THE c-Src PATHWAY

  • AP22408, AP23236, AP23451
  • AP23464
  • AZD0530
  • AZM475271 (M475271)
  • BMS-354825
  • GN963
  • SKI-606
  • Other Programs


LIST OF EXHIBITS

Exhibit 1 - Drugs in Development Targeting the Src Pathway


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